The spacecraft executed a deboost maneuver at 3:26 p.m., November 10, while 352,370 kilometers from the earth and 1,260 kilometers from the moon and traveling at a speed of 5,028 kilometers per hour. The maneuver permitted the lunar gravitational field to pull the spacecraft into the planned initial orbit around the moon. On November 15, a micrometeoroid hit was detected by one of the 20 thin-walled pressurized sensors.

The spacecraft was transferred into its final close-in orbit around the moon at 5:58 p.m. November 15 and the photo-acquisition phase of Lunar Orbiter II's mission began November 18. Thirteen selected primary potential landing sites and a number of secondary sites were to be photographed. By the morning of November 25, the spacecraft had taken 208 of the 211 photographs planned and pictures of all 13 selected potential landing sites. It also made 205 attitude change maneuvers and responded to 2,421 commands.

The status report of the Lunar Orbiter II mission as of November 28 indicated that the first phase of the photographic mission was completed when the final photo was taken on the afternoon of November 25. On November 26, the developing web was cut with a hot wire in response to a command from the earth. Failure to achieve the cut would have prevented the final readout of all 211 photos. Readout began immediately after the cut was made. One day early, December 6, the readout terminated when a transmitter failed, and three medium-resolution and two high-resolution photos of primary site 1 were lost. Full low-resolution coverage of the site had been provided, however, and other data continued to be transmitted. Three meteoroid hits had been detected. References: 2, 6, 16, 278.

Major objectives of the mission were to rendezvous and dock and to evaluate extravehicular activities (EVA). Among the secondary objectives were tethered vehicle evaluation, experiments, third revolution rendezvous and docking, automatic reentry demonstration, docked maneuvering for a high-apogee excursion, docking practice, systems tests, and Gemini Agena target vehicle (GATV) parking. The high-apogee excursion was not attempted because an anomaly was noted in the GATV primary propulsion system during insertion, and parking was not attempted because the GATV's attitude control gas was depleted. All other objectives were achieved. Nine spacecraft maneuvers effected rendezvous with the GATV. The onboard radar malfunctioned before the terminal phase initiate maneuver, but the crew used onboard backup procedures to calculate the maneuvers. Rendezvous was achieved at 3 hours 46 minutes ground elapsed time, docking 28 minutes later. Two phasing maneuvers, using the GATV secondary propulsion system, were accomplished, but the primary propulsion system was not used. The first of two periods of standup EVA began at 19 hours 29 minutes into the flight and lasted for 2 hours 29 minutes. During a more than two-hour umbilical EVA which began at 42 hours 48 minutes, Aldrin attached a 100-foot tether from the GATV to the spacecraft docking bar. He spent part of the period at the spacecraft adapter, evaluating various restraint systems and performing various basic tasks. The second standup EVA lasted 55 minutes, ending at 67 hours 1 minute ground elapsed time. The tether evaluation began at 47 hours 23 minutes after liftoff, with the crew undocking from the GATV. The tether tended to remain slack, although the crew believed that the two vehicles did slowly attain gravity-gradient stabilization. The crew jettisoned the docking bar and released the tether at 51 hours 51 minutes. Several spacecraft systems suffered problems during the flight. Two fuel cell stacks failed and had to be shut down, while two others experienced significant loss of power. At 39 hours 30 minutes ground elapsed time, the crew reported that little or no thrust was available from two orbit attitude and maneuver thrusters. References: 2, 6, 26, 33,60.